High‐dimensional spectral cytometry identifies follicular regulatory CD8 <sup>+</sup> T cells in diffuse large B‐cell lymphoma
Our study highlights the utility of high-dimensional computational cytometry in elucidating T-cell subpopulations, including an increased frequency of CD8<sup>+</sup> follicular regulatory T cells and their communication patterns within the DLBCL TME. This unbiased approach sheds light on novel cellular mechanisms in DLBCL, uncovering potential targets and biomarkers for immunotherapy.
Authors
- Pierre Tonnerre (ORCID: https://orcid.org/0000-0002-1719-9736)
- Phuong N. Le (ORCID: https://orcid.org/0000-0001-7800-064X)
- Véronique Meignin (ORCID: https://orcid.org/0000-0003-0502-9489)
- Loïc Renaud (ORCID: https://orcid.org/0000-0001-7213-9464)
- Catherine Thieblemont
- Alba Díaz Herrero
- Vassili Soumelis
- Véronique Blanc
Institutions
- Inserm (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Délégation Ile-de-France Sud (FR)
- Institut Cochin (FR)
- Hôpital Saint-Louis (FR)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70062
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Laboratoire d'Excellence Inflamex
- Fondation ARC pour la Recherche sur le Cancer