Evaluation of the Application of Novel Smart Release Cooling Agent in Neurocosmetic Products

ABSTRACT This study developed a novel cooling agent based on smart encapsulation technology and systematically evaluated its efficacy and performance characteristics. The active component of the cooling agent specifically targets the cold‐sensing receptor TRPM8, triggering neural signal transmission to the central nervous system and thereby inducing a neurophysiological cooling sensation. The intensity of the cooling response was positively correlated with the concentration of the agent, whereas its duration remained consistent across concentrations, lasting between 1.5 and 2.5 h. In comparison with other cooling ingredients, the developed cooling agent exhibited significant advantages in both the intensity and persistence of the cooling effect. The formulation employs an intelligent water‐triggered release mechanism that effectively extends the release time of the cooling components. Consequently, the cooling agent delivers a strong and sustained cooling effect without causing skin irritation. These attributes underscore its broad application potential in cosmetics, food, and daily chemical products.