Structural immunotherapy: Harnessing chemical design to build powerful next-generation therapeutics
Structural immunotherapy relies on the structural features of immunotherapeutics in addition to component identity to influence biodistribution, intra- or extracellular localization, target engagement, and processing kinetics. This strategy is poised to redefine how immunotherapeutics mobilize immunity against disease and transform our ability to harness structure-function relationships to enhance clinical outcomes.
Authors
- Sergej Kudruk (ORCID: https://orcid.org/0000-0002-6402-0292)
- Sarah Hurst Petrosko (ORCID: https://orcid.org/0000-0002-7319-3232)
- Michelle H. Teplensky (ORCID: https://orcid.org/0000-0003-4664-420X)
- Chad Alexander Mirkin (ORCID: https://orcid.org/0000-0002-6634-7627)
- Julianna N. Bourgeois (ORCID: https://orcid.org/0000-0003-2454-2579)
Institutions
- Boston University (US)
- Northwestern University (US)
- National Institute for Nanotechnology (CA)
- Chan Zuckerberg Initiative (United States) (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1073/pnas.2409553122
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00