Dissecting the role of plasma and urinary metabolites in bone mineral density: Evidence from a bidirectional univariable Mendelian randomization study
This research deepens our insight into metabolite and bone mineral density interactions. The three lipid-related metabolites with causal links to bone density could be potential markers and targets for osteoporosis treatment, especially in middle-aged and older adults.
Authors
- Xinglang Wang (ORCID: https://orcid.org/0009-0000-9359-567X)
- Yuanquan Chen (ORCID: https://orcid.org/0000-0002-1062-3450)
- Tianwei Xie (ORCID: https://orcid.org/0000-0002-0270-0399)
- Shuai Fan (ORCID: https://orcid.org/0000-0002-7120-3556)
- Guojian Li
- Jiacong Hong
- Zhipeng Chen (ORCID: https://orcid.org/0000-0003-0418-5236)
- Chenhao Xu (ORCID: https://orcid.org/0000-0003-2655-0302)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Hezhou University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.exger.2025.112945
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00