Novel 2 <i>H</i> -Pyrazolo[3,4- <i>d</i> ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Diseases
The invention discloses novel NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inhibitors featuring a 2<i>H</i>-pyrazolo-[3,4-<i>d</i>]-thiazole scaffold. These NLRP3 inhibitors exhibit significant potential as therapeutic candidates for neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Authors
- Zhendong Song (ORCID: https://orcid.org/0000-0002-1657-6325)
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
Institutions
- Emory University (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00626
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00