Integrated Metagenomic and Metabolomic Analyses Reveal a Microbiota–Metabolite Axis Associated with Gallstone Pathogenesis
This study provides evidence consistent with a contributory role of gut microbiota-metabolite dysregulation in gallstone pathogenesis. Specific taxa (<i>A. muciniphila</i>, <i>CAG-448</i>) and metabolites (GDCA, N-acetylarginine) may serve as potential biomarkers or targets for microbiota- and diet-based prevention strategies.
Authors
- Anliang Huang
- Kai Luo (ORCID: https://orcid.org/0000-0003-4023-7259)
- Muhammad Yousaf Shad (ORCID: https://orcid.org/0000-0002-3541-6220)
- Peiyuan Yin (ORCID: https://orcid.org/0000-0003-3639-3363)
- Yuzhu Jin
- Xudong Zhang (ORCID: https://orcid.org/0000-0001-6615-6671)
- He Bai
- Guixin Zhang (ORCID: https://orcid.org/0009-0007-5583-4271)
- Yuting Zhao (ORCID: https://orcid.org/0000-0003-4332-6329)
- Xu Sun (ORCID: https://orcid.org/0009-0000-6489-7775)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2025-10-31
- DOI
- https://doi.org/10.3390/metabo15110714
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00