Targeting the ATM–TGS1–BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma
The ATM-TGS1-BRCA1 signaling axis is a critical regulator of DNA repair that can be targeted to overcome genotoxic therapy resistance, providing a promising therapeutic strategy that could transform pancreatic cancer treatment.
Authors
- Changying Li (ORCID: https://orcid.org/0000-0002-0115-7507)
- Zhenyu Huo (ORCID: https://orcid.org/0000-0002-9841-5081)
- Somaira Nowsheen (ORCID: https://orcid.org/0000-0001-7174-5366)
- Min Deng (ORCID: https://orcid.org/0000-0002-7133-8100)
- Guang-Yi Sun (ORCID: https://orcid.org/0000-0003-3379-4209)
- Zhenkun Lou (ORCID: https://orcid.org/0000-0003-1938-3091)
- Zhihua Liu (ORCID: https://orcid.org/0000-0003-4242-033X)
- Xinyan Li (ORCID: https://orcid.org/0000-0003-0710-0293)
- Chunyan Wang
- X.-M. Zhao (ORCID: https://orcid.org/0000-0002-3857-2739)
- Khaled Aziz
- Wenjuan Kang (ORCID: https://orcid.org/0000-0002-9727-5005)
- Xin Xu (ORCID: https://orcid.org/0000-0001-8838-6646)
Institutions
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Johns Hopkins Medicine (US)
- Peking Union Medical College Hospital (CN)
- University of Iowa Hospitals and Clinics (US)
- National Cancer Center (US)
- Mayo Clinic in Arizona (US)
- Physicians' Clinic of Iowa (US)
- Mayo Clinic in Florida (US)
- Shandong Provincial QianFoShan Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1435
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00