Cancer Prevention at Work (CPW) project: Rationale, framework and research protocol
Chronic infections such as Helicobacter pylori (Hp), Hepatitis C virus (HCV), and Human Papillomavirus (HPV) significantly contribute to the global cancer burden, necessitating targeted and cost-effective prevention strategies. The Cancer Prevention at Work (CPW) project pioneers an innovative approach by integrating primary prevention interventions into occupational health surveillance (OHS) programs, thus leveraging existing workplace infrastructure for a large-scale impact. CPW aims to screen and treat Hp and HCV infections, and promote HPV vaccination, targeting not only workers but also their household members. CPW aims to support accessibility, facilitate earlier detection, and strengthen cancer prevention at a population level. The project employs a micro-elimination strategy for HCV, supports data-driven risk assessment for Hp and HPV, and promotes evidence-based communication to reduce HPV vaccine hesitancy. A comprehensive data management framework ensures harmonized data collection, integration, and cost-effectiveness analysis, aiming at providing robust evidence for policy recommendations. Through pilot studies conducted across four European countries, CPW assesses the feasibility, cost-effectiveness, and economic sustainability, with the potential to inform future occupational cancer prevention initiatives across Europe. This work summarizes the CPW project's research framework designed to integrate infection-related cancer prevention into workplace health programs across Europe. It details the project's goals, methods, and discusses the impact on occupational cancer prevention.
Authors
- Adonina Tardón (ORCID: https://orcid.org/0000-0001-5150-1209)
- Giulia Collatuzzo (ORCID: https://orcid.org/0000-0002-2309-7365)
- Dana Mateș (ORCID: https://orcid.org/0000-0002-6219-9807)
- Guillermo Fernández‐Tardón (ORCID: https://orcid.org/0000-0002-7680-158X)
- Daniel Vencovsky
- Anna Schneider‐Kamp (ORCID: https://orcid.org/0000-0001-9822-6996)
- Mario E. Magaña (ORCID: https://orcid.org/0000-0002-1858-0723)
- Marta María Rodríguez-Suárez (ORCID: https://orcid.org/0000-0003-0835-5837)
- Monireh Sadat Seyyedsalehi (ORCID: https://orcid.org/0000-0002-9063-9128)
- Stefano Giordani (ORCID: https://orcid.org/0000-0001-6222-5887)
- Sabato Mellone (ORCID: https://orcid.org/0000-0001-7688-0188)
- Renata Gili (ORCID: https://orcid.org/0009-0004-9631-1870)
- Felipe Augusto Pinto-Vidal (ORCID: https://orcid.org/0000-0002-7159-9781)
- Jana Oravec Bérešová (ORCID: https://orcid.org/0000-0002-9163-5866)
- Florina Georgeta Popescu (ORCID: https://orcid.org/0000-0002-9967-2653)
- Ángel Honrado
- Gianluca Massimino (ORCID: https://orcid.org/0000-0002-0512-1659)
- Søren Askegaard (ORCID: https://orcid.org/0000-0001-9279-4706)
- Bruno Daniele (ORCID: https://orcid.org/0000-0002-2638-3156)
- Eleonóra Fabiánová (ORCID: https://orcid.org/0000-0002-5519-8427)
- Catharina Roth (ORCID: https://orcid.org/0000-0002-3346-1191)
- Michel Wensing (ORCID: https://orcid.org/0000-0001-6569-8137)
- Violeta Calotă
- Valentina Biagioli (ORCID: https://orcid.org/0000-0002-8713-2051)
- Zuzana Klöslová
- Alessandro Godono (ORCID: https://orcid.org/0000-0001-8095-5461)
- Giulia Fiorini (ORCID: https://orcid.org/0000-0003-0381-8302)
- Serena Moscato (ORCID: https://orcid.org/0000-0002-0538-650X)
- Magdalena Kostrzewa (ORCID: https://orcid.org/0000-0002-3395-5191)
- Marina Ruxandra Oțelea (ORCID: https://orcid.org/0000-0002-0829-0562)
- P. Boffetta
- Maria Teresa Cella (ORCID: https://orcid.org/0000-0001-8958-090X)
- Miriam Kočtúchová Blažinová
- Robert Vilček
- Iulia Crull
- Egle Gorra
- Ariele Santello
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- Universidad de Oviedo (ES)
- University of Southern Denmark (DK)
- Heidelberg University (DE)
- University of Business in Prague (CZ)
- University Hospital Heidelberg (DE)
- Stony Brook School (US)
- Romanian Society of Nephrology (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- Laboratori Guglielmo Marconi (Italy) (IT)
- Public Health Authority of the Slovak Republic (SK)
- Ospedale San Paolo (IT)
- Agenzia Regionale Prevenzione e Ambiente della Regione Emilia-Romagna (IT)
- Light Prescriptions Innovators (Spain) (ES)
- The US Oncology Network (US)
- Podbrezová Iron Works (Slovakia) (SK)
- Department of Public Health (US)
- Slovak Environmental Agency (SK)
- Instituto Nacional de Silicosis (ES)
- University of Turin (IT)
- Stony Brook University (US)
- University of Bologna (IT)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1371/journal.pone.0335752
- Citations
- 3
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- European Commission
- HORIZON EUROPE Framework Programme