Breath Isoprene Sensor Based on Quartz-Enhanced Photoacoustic Spectroscopy
Isoprene, the most abundant endogenous hydrocarbon in human breath, is a promising biomarker for metabolic and cardiovascular diseases. In this paper, we present the detection of isoprene in exhaled breath using the off-beam Quartz-Enhanced Photoacoustic Spectroscopy (QEPAS) method. The sensor employs a homemade quantum cascade laser emitting at 11.03 μm. We use numerical simulations to evaluate the impact of interfering gases (CO<sub>2</sub> and H<sub>2</sub>O) and optimize the laser modulation parameters. The limit of detection reached for 1 s acquisition time is close to 220 parts per billion in volume (ppbv) with a normalized noise equivalent absorption (NNEA) of 1.1×10-8cm-1·W·Hz-1/2. Breath measurements conducted on healthy volunteers reveal a significant increase in isoprene concentration from resting levels (~250-350 ppbv) to elevated levels (~450-650 ppbv) after moderate physical exercise.
Authors
- Eric Rosenkrantz (ORCID: https://orcid.org/0000-0002-6399-882X)
- D. A. Díaz-Thomas (ORCID: https://orcid.org/0009-0003-0920-9986)
- Farès Gouzi (ORCID: https://orcid.org/0000-0001-8970-866X)
- M. Bahriz (ORCID: https://orcid.org/0000-0001-6819-1067)
- Diba Ayache (ORCID: https://orcid.org/0009-0000-9406-7836)
- Julien Charensol
- Fanny Pagès (ORCID: https://orcid.org/0009-0002-0085-2820)
- M. S. Aouadi
- A. Vicet (ORCID: https://orcid.org/0000-0002-5709-3151)
- Tarek Seoudi
- А. Н. Баранов (ORCID: https://orcid.org/0000-0003-4940-6098)
- Fadia Abou Abou Naoum (ORCID: https://orcid.org/0009-0002-5846-2083)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
Publication Details
- Journal
- Sensors
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3390/s25216732
- Primary Topic
- Spectroscopy and Laser Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche