Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers
SIAH2 was identified to be one of the key efferocytosis genes and associated with poor prognosis of DFU. Protective upregulation of SIAH2 was involved in angiogenesis, keratinocyte migration and cell-to-cell communication mediated by efferocytosis in DFU wound healing.
Authors
- Zhiwei Xue (ORCID: https://orcid.org/0000-0002-9761-0838)
- Yulong He (ORCID: https://orcid.org/0000-0002-0265-5946)
- Junzhi Liu (ORCID: https://orcid.org/0000-0001-7146-0942)
- Fei Yan (ORCID: https://orcid.org/0000-0002-0049-8588)
- Xuchen Liu (ORCID: https://orcid.org/0000-0001-7054-743X)
- Xinyu Wang (ORCID: https://orcid.org/0000-0001-7549-2845)
- Chao Li (ORCID: https://orcid.org/0000-0003-1568-9704)
- Jiwei Wang (ORCID: https://orcid.org/0000-0002-5230-3658)
- Ziyi Tang
- Ning Yang (ORCID: https://orcid.org/0000-0002-9158-4712)
- Sun Q (ORCID: https://orcid.org/0009-0009-1281-278X)
- Nan Su (ORCID: https://orcid.org/0000-0002-9405-6018)
- Jiangli Zhao
- Haoyong Jin
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1371/journal.pone.0334163
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China