Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring β-cell function, reducing ectopic fat, and preventing type 2 diabetes
High 1 h-PG indicates an intermediate metabolic state with pathophysiological changes more severe than in NGR but milder than in IGR. In people with high 1 h-PG, LI significantly improved insulin sensitivity and β-cell function and reduced ectopic lipid deposition and the risk of developing T2D compared to IGR. These findings highlight the value of 1 h-PG as a clinically useful biomarker, providing a critical window for early intervention to reverse core metabolic defects driving prediabetes and T2D.
Authors
- Norbert Stefan (ORCID: https://orcid.org/0000-0002-2186-9595)
- REINER JUMPERTZ VON SCHWARTZENBERG
- Andreas L. Birkenfeld (ORCID: https://orcid.org/0000-0003-1407-9023)
- Jürgen Machann (ORCID: https://orcid.org/0000-0002-4458-5886)
- Marlene Ganslmeier
- Michael Bergman (ORCID: https://orcid.org/0000-0003-2589-2976)
- Fritz Schick (ORCID: https://orcid.org/0000-0002-4231-3406)
- Leontine Sandforth
- Kοnstantinos Kantartzis (ORCID: https://orcid.org/0000-0002-0584-1138)
- Andreas Fritsche (ORCID: https://orcid.org/0000-0002-4987-1961)
- Hubert Preißl (ORCID: https://orcid.org/0000-0002-8859-4661)
- Sarah Katzenstein
- Arvid Sandforth (ORCID: https://orcid.org/0009-0009-5374-1260)
- Yiying Wang (ORCID: https://orcid.org/0000-0003-4053-6523)
- Yurong Cheng
Institutions
- BG Klinik Tübingen (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- New York University (US)
- University of Tübingen (DE)
Publication Details
- Journal
- Metabolism
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.metabol.2025.156430
- Citations
- 2
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 2.59