Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis

This study provides evidence that genetically predicted higher levels of saturated and linoleic acids are causally associated with increased PsA risk. These findings highlight potential dietary targets for PsA prevention and warrant investigation into lipid-mediated inflammatory pathways in PsA pathogenesis. Key Points • This study demonstrated a significant positive association between genetically predicted circulating levels of saturated fatty acids (OR = 1.141, 95%CI 1.010-1.289)/linoleic acid (OR = 1.154, 95%CI 1.032-1.289) and the risk of psoriatic arthritis. • These findings provided foundational insights for developing dietary interventions aimed at preventing and treating psoriatic arthritis. • Through a two-sample Mendelian randomization coupled with fixed-effects meta-analysis, the robustness of causal inferences was rigorously validated. • Collectively, these results advance the understanding of immunometabolic mechanisms underlying chronic inflammatory disorders.