Target and off-target effects of vibegron on smooth muscle contraction of human detrusor and prostate tissues
Similar to mirabegron, improvements of storage symptoms by vibegron involve mechanisms beyond inhibition of voiding contractions. Off-target effects occur with 10 µM, and include inhibition of neurogenic contractions and antagonism of prostatic α<sub>1A</sub>-adrenoceptors. Vibegron effects in the prostate may differ between patients with low BPH progression, and patients needing surgery for BPH.
Authors
- Yajie Xu (ORCID: https://orcid.org/0000-0002-2296-3508)
- Martin Hennenberg (ORCID: https://orcid.org/0000-0003-1305-6727)
- Leo Federico Stadelmeier (ORCID: https://orcid.org/0009-0005-3053-944X)
- Michael Brandstetter
- Philipp Weinhold (ORCID: https://orcid.org/0000-0002-9144-9289)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Oluwafemi Ezekiel Kale (ORCID: https://orcid.org/0000-0003-2965-1723)
- Sheng Hu
- Patrick Keller (ORCID: https://orcid.org/0000-0001-5176-4500)
- Alexander Tamalunas
Institutions
- LMU Klinikum (DE)
- Klinik und Poliklinik für Urologie (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Naunyn-Schmiedeberg s Archives of Pharmacology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s00210-025-04762-z
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council