Does telomere length mediate the association between early life adversity and mental health in childhood?

ELA influences children's mental well-being and telomere length. Surprisingly, telomere length was longer following ELA, which may be a compensatory mechanism to regulate the effects of accelerated telomere attrition in response to adversity. Further research is needed to understand these complex and dynamic relationships across the life-course.

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Publication Details

Journal
Journal of Affective Disorders
Published
2025-11-03
DOI
https://doi.org/10.1016/j.jad.2025.120600
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
Field-Weighted Citation Impact
0.00
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article

Does telomere length mediate the association between early life adversity and mental health in childhood?

Zaneta M. Thayer, Karen E. Waldie, Caroline Walker, Emma Marks et al.
Journal of Affective Disorders
Telomeres, Telomerase, and Senescence
article

Does telomere length mediate the association between early life adversity and mental health in childhood?

Zaneta M. Thayer, Karen E. Waldie, Caroline Walker, Emma Marks, Russell G. Snell, Benjamin D. Fletcher, Kien Ly, Susan Morton, Sarah Knowles, Gemma Hughes-Waldon
article en

Abstract

ELA influences children's mental well-being and telomere length. Surprisingly, telomere length was longer following ELA, which may be a compensatory mechanism to regulate the effects of accelerated telomere attrition in response to adversity. Further research is needed to understand these complex and dynamic relationships across the life-course.

Journal of Affective DisordersVol. 394(Pt B)
Dartmouth College (US), Goethe University Frankfurt (DE), Laidlaw College (NZ), University of Auckland (NZ), The George Institute for Global Health (AU), Brain Research New Zealand (NZ), Auckland War Memorial Museum
Openalex Percentile: Top 60%
Telomeres, Telomerase, and Senescence
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