Endothelin-1 and Cardio-Kidney Events among Patients with Chronic Kidney Disease, Diabetes, and Anemia
Among patients with established CKD, T2DM, and anemia, higher baseline ET-1 was associated with a higher subsequent risk of kidney outcomes, HF events, and all-cause death. Whether higher ET-1 predicts responsiveness to ET receptor antagonism warrants further investigation.
Authors
- Petr Jarolı́m (ORCID: https://orcid.org/0000-0002-9612-8652)
- Robert D. Toto (ORCID: https://orcid.org/0000-0001-9531-1749)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Giuseppe Remuzzi (ORCID: https://orcid.org/0000-0002-6194-3446)
- Finnian R. Mc Causland (ORCID: https://orcid.org/0000-0002-0299-0533)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Andrew S. Levey (ORCID: https://orcid.org/0000-0003-1491-501X)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Martina M. McGrath (ORCID: https://orcid.org/0000-0001-6210-9341)
- Emmanuel A. Burdmann (ORCID: https://orcid.org/0000-0002-7644-8579)
- Ajay Singh (ORCID: https://orcid.org/0000-0003-2933-4058)
- Kai-Uwe Eckardt
- Marc A. Pfeffer
Institutions
- Brigham and Women's Hospital (US)
- Tufts Medical Center (US)
- Harvard University (US)
- Mario Negri Institute for Pharmacological Research (IT)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1159/000549255
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00