Social interaction mitigates cognitive impairments and tau pathology in socially isolated aged mice
Our findings demonstrate that social interaction with young counterparts can rescue isolation-induced cognitive deficits in aged mice, potentially through mechanisms involving tau phosphorylation regulation and synaptic protein restoration. These results provide preclinical evidence supporting social intervention strategies for preventing cognitive decline in socially isolated elderly individuals.
Authors
- Jiayu Zeng (ORCID: https://orcid.org/0009-0001-6502-878X)
- Zheng Liang (ORCID: https://orcid.org/0009-0008-3006-2727)
- Wanbing Huang (ORCID: https://orcid.org/0000-0002-4548-6046)
- Adan Fu (ORCID: https://orcid.org/0000-0001-9199-8694)
- Hongmei Zhu (ORCID: https://orcid.org/0000-0002-6935-8284)
- Zhenshan Bao (ORCID: https://orcid.org/0000-0002-7665-3396)
Institutions
- Jianghan University (CN)
- Central Hospital of Wuhan (CN)
Publication Details
- Journal
- Journal of Alzheimer s Disease Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/25424823251394408
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00