Compartment-Specific NK Cell Phenotypes Reveal Distinct Maturation and Activation States in Inflammatory Arthritis
This paired high-dimensional analysis revealed systemic and local alterations in NK cell subsets shaped by co-existing developmental stages and immune regulatory mechanisms. Cellular interaction mapping indicated that neutrophils are a main interaction-partner of NK cells in inflamed joints. .
Authors
- Daniel Hübschmann (ORCID: https://orcid.org/0000-0002-6041-7049)
- Maren Claus (ORCID: https://orcid.org/0000-0001-8732-0645)
- Carsten Watzl (ORCID: https://orcid.org/0000-0001-5195-0995)
- Schayan Yousefian (ORCID: https://orcid.org/0000-0003-0902-0369)
- Simon Haas (ORCID: https://orcid.org/0000-0001-9227-2051)
- Jörg H. W. Distler (ORCID: https://orcid.org/0000-0001-7408-9333)
- Wolfgang Merkt (ORCID: https://orcid.org/0000-0003-3235-4906)
- Hanns‐Martin Lorenz (ORCID: https://orcid.org/0000-0003-0305-0946)
- Tarik Exner (ORCID: https://orcid.org/0000-0002-3131-2133)
- Lea Rodon
- Franca Sophie Deicher
- Steven Leonhardt
Institutions
- Queen Mary University of London (GB)
- German Cancer Research Center (DE)
- TU Dortmund University (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- Düsseldorf University Hospital (DE)
- German Cancer Society (DE)
- National Center for Tumor Diseases (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- DKFZ-ZMBH Alliance (DE)
- Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1159/000548548
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00