First-line immunotherapy ± chemotherapy with or without upfront stereotactic radiotherapy (SRT) in patients with Non-Small cell lung cancer (NSCLC) with asymptomatic brain metastases
In this multicentric retrospective analysis of patients with asymptomatic brain metastases upfront SRT was associated with an improved intracranial PFS and was well tolerated but median OS and the rate of patients developing symptomatic brain progression were similar to patients without upfront SRT.
Authors
- Lorenz Frehner
- Franca Wagner (ORCID: https://orcid.org/0000-0001-7502-4814)
- Sacha I. Rothschild (ORCID: https://orcid.org/0000-0003-1304-9340)
- Tobias Finazzi (ORCID: https://orcid.org/0000-0002-4118-4171)
- Sabrina Marini
- David König (ORCID: https://orcid.org/0000-0003-3559-6855)
- Antonia Stamatiou
- Anna Allemann
- Martin Früh (ORCID: https://orcid.org/0000-0002-4047-1734)
- Sämi Schär (ORCID: https://orcid.org/0000-0001-6108-4832)
- Stefanie Hayoz (ORCID: https://orcid.org/0000-0002-2265-6559)
- Michael Mark
- Yannis Metaxas (ORCID: https://orcid.org/0000-0001-5290-9660)
- Ekin Ermiş (ORCID: https://orcid.org/0000-0002-6974-6762)
- Patrizia Froesch (ORCID: https://orcid.org/0000-0002-8140-1249)
- Sabine Schmid (ORCID: https://orcid.org/0000-0003-0840-3253)
- Laetitia Mauti (ORCID: https://orcid.org/0000-0002-6652-1947)
- Wolf-Dieter Janthur (ORCID: https://orcid.org/0009-0005-4139-2260)
- Philip Speicher
- Verena Petermichl
Institutions
- University of Bern (CH)
- University of Lucerne (CH)
- University of St.Gallen (CH)
- University Hospital of Bern (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Basel (CH)
- Ente Ospedaliero Cantonale (CH)
- Kantonsspital Winterthur (CH)
- Swiss Cancer League (CH)
- Kantonsspital Münsterlingen (CH)
- Kantonsspital Baden (CH)
- Swiss Group For Clinical Cancer Research (CH)
- Spital Thurgau (Switzerland) (CH)
- Kantonsspital Aarau (CH)
Publication Details
- Journal
- Lung Cancer
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.lungcan.2025.108813
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00