Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
In an acute responding model of radiation-induced abdominal toxicity, the FLASH sparing effect was substantially reduced with a two-fraction regimen and completely absent with a ten-fraction regimen. These findings suggest that the benefit of FLASH may be limited at lower doses per fraction and highlight the need for further studies in other clinically relevant models to better define the boundaries of its therapeutic applicability.
Authors
- Raphaël Moeckli (ORCID: https://orcid.org/0000-0002-5885-934X)
- Till T. Böhlen (ORCID: https://orcid.org/0000-0001-7408-0187)
- Claude Bailat (ORCID: https://orcid.org/0000-0002-0386-4782)
- Veljko Grilj (ORCID: https://orcid.org/0000-0001-6573-8063)
- Fernanda Herrera (ORCID: https://orcid.org/0000-0001-7984-0472)
- R. Geyer (ORCID: https://orcid.org/0009-0007-5370-8300)
- P Devanand
- Anouk Sesink (ORCID: https://orcid.org/0009-0000-3216-7444)
- Luca Soutter
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- Institute of Radiation Physics (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.radonc.2025.111262
- Citations
- 3
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 4.08