Assessing the Tumor Suppressive Impact and Regulatory Mechanisms of SPDEF Expression in Breast Cancer
SPDEF functions as a tumor suppressor in breast cancer, with reduced expression linked to poor outcomes, aggressive molecular features, and epigenetic regulation. These findings highlight SPDEF and DNMT-driven methylation as potential prognostic biomarkers for enhanced risk stratification and targets for novel therapies, particularly in Basal breast cancers.
Authors
- Suresh K. Alahari (ORCID: https://orcid.org/0000-0002-9651-6727)
- Maninder Khosla
- Maansi Solanky (ORCID: https://orcid.org/0009-0000-5225-3518)
Institutions
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-02
- DOI
- https://doi.org/10.3390/cancers17213556
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00