Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

Sarocladium spp. are filamentous fungi commonly associated with plant diseases and only rarely cause hyalohyphomycosis in humans. Immunosuppressed patients are at risk for this infection, which typically presents with skin and subcutaneous lesions that may eventually disseminate to internal organs. This study reports a case of a man in intensive care following SARS-CoV-2 infection. During hospitalization, he developed neutropenia, persistent fever, and a cavitary lung lesion. Sarocladium spp. was isolated from blood cultures, and the patient was treated with voriconazole, leading to a successful cure. To our knowledge, this is the first reported case of Sarocladium implicatum infection in a COVID-19 patient, underscoring the importance of monitoring opportunistic fungal infections in immunocompromised individuals, particularly during epidemics and pandemics.

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Publication Details

Journal
Revista do Instituto de Medicina Tropical de São Paulo
Published
2025-01-01
DOI
https://doi.org/10.1590/s1678-9946202567075
Primary Topic
Fungal Infections and Studies
Type
article
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article

Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

Márcia Regina von Zeska Kress, Gilberto Gambero Gaspar, Ludmilla Tonani, Patrícia Helena Grizante Barião et al.
Revista do Instituto de Medicina Tropical de São Paulo
Fungal Infections and Studies
article

Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

Márcia Regina von Zeska Kress, Gilberto Gambero Gaspar, Ludmilla Tonani, Patrícia Helena Grizante Barião, Roberto Martínez, Otávio Guilherme Gonçalves de Almeida
article en

Abstract

Sarocladium spp. are filamentous fungi commonly associated with plant diseases and only rarely cause hyalohyphomycosis in humans. Immunosuppressed patients are at risk for this infection, which typically presents with skin and subcutaneous lesions that may eventually disseminate to internal organs. This study reports a case of a man in intensive care following SARS-CoV-2 infection. During hospitalization, he developed neutropenia, persistent fever, and a cavitary lung lesion. Sarocladium spp. was isolated from blood cultures, and the patient was treated with voriconazole, leading to a successful cure. To our knowledge, this is the first reported case of Sarocladium implicatum infection in a COVID-19 patient, underscoring the importance of monitoring opportunistic fungal infections in immunocompromised individuals, particularly during epidemics and pandemics.

Revista do Instituto de Medicina Tropical de São PauloVol. 67
Universidade de São Paulo (BR)
Openalex Percentile: Top 57%
Fungal Infections and Studies
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Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient — Márcia Regina von Zeska Kress, Gilberto Gambero Gaspar, et al. · Revista do Instituto de Medicina Tropical de São Paulo (2025) | TGRS Research Map | TGRS