Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice
Here, we show that KAT II deletion reshapes regional Trp metabolism and amplifies oxidative and excitotoxic imbalance. Although domain-wide behavioral measures, spanning cognition, sociability, and motor coordination, remained largely unchanged, these neurochemical alterations signify a latent emotional bias rather than overt depressive-like behavior. This work, therefore, refines prior findings by delineating KAT II-linked biochemical vulnerability as a potential substrate for stress-reactive affective dysregulation.
Authors
- Keiko Takeda (ORCID: https://orcid.org/0000-0002-3473-7786)
- Eleonóra Spekker (ORCID: https://orcid.org/0000-0003-0888-9353)
- Ágnes Fehér
- József Toldi (ORCID: https://orcid.org/0000-0001-7355-0503)
- Masaru Tanaka (ORCID: https://orcid.org/0000-0003-4383-4024)
- László Vécsei (ORCID: https://orcid.org/0000-0001-8037-3672)
- Péter Monostori (ORCID: https://orcid.org/0000-0003-3591-6054)
- Annamária Fejes-Szabó
- Zsolt Galla (ORCID: https://orcid.org/0000-0002-9166-1212)
- Mónika Szűcs (ORCID: https://orcid.org/0000-0002-8791-9452)
- Hiromi Inoue (ORCID: https://orcid.org/0000-0002-1614-467X)
- Diána Martos (ORCID: https://orcid.org/0000-0001-7596-9965)
- Ágnes Szabó (ORCID: https://orcid.org/0000-0002-3435-8866)
- Kinuyo Ozaki
- Sayo Yamamoto
- Etsuro Ono
Institutions
- Kyushu University (JP)
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- MTA-SZTE Research Group on Artificial Intelligence (HU)
Publication Details
- Journal
- Cells
- Published
- 2025-10-31
- DOI
- https://doi.org/10.3390/cells14211711
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00