Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Milrinone may serve as a feasible adjunct or bridging therapy for PPHN when iNO is unavailable. However, its use requires careful hemodynamic and neurological monitoring, particularly in very preterm infants. Further studies are needed to confirm safety and define optimal dosing across gestational ages.

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Publication Details

Journal
Pediatric Reports
Published
2025-11-03
DOI
https://doi.org/10.3390/pediatric17060116
Primary Topic
Neonatal Respiratory Health Research
Type
article
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article

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Łukasz Minarowski, Łukasz Osiński, Alina Minarowska et al.
Pediatric Reports
Neonatal Respiratory Health Research
article

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Łukasz Minarowski, Łukasz Osiński, Alina Minarowska, Anna Doboszyńska, Sławomir Dariusz Szajda, Norbert Dera
article en

Abstract

Milrinone may serve as a feasible adjunct or bridging therapy for PPHN when iNO is unavailable. However, its use requires careful hemodynamic and neurological monitoring, particularly in very preterm infants. Further studies are needed to confirm safety and define optimal dosing across gestational ages.

Pediatric ReportsVol. 17(6)
Medical University of Białystok (PL), University Clinical Hospital In Bialystok (PL), University of Computer Sciences and Economics in Olsztyn (PL), Postgraduate School of Molecular Medicine (PL), University of Warmia and Mazury in Olsztyn (PL), Gdańsk Medical University (PL)
Openalex Percentile: Top 54%
Neonatal Respiratory Health Research
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