Chemical composition and cytotoxic activity of Saudi Arabia <i>Artemisia sieberi</i> essential oils
<i>Artemisia sieberi</i> Besser (family Asteraceae) is a perennial aromatic wild plant native to the northern region of Saudi Arabia, specifically collected near Zahwah. Analysis of the volatile oil extracted <i>via</i> hydrodistillation (HD) identified 48 components, accounting for 99.31% of its total composition. The major constituents identified were α-pinene (24.65%) and 1,8-cineole (11.39%). The growth inhibitory activity of <i>A. sieberi</i> essential oil (EO) was evaluated against three human tumour cell lines colon (HCT-116), liver (HepG2), and breast (MCF-7). Results demonstrated notable cytotoxic activity, with particularly significant effects observed against the breast cancer (MCF-7) cell line.
Authors
- M. T. M. EL‐WASSIMY
- Hazem A. Albadry
- Mohamed‐Elamir F. Hegazy (ORCID: https://orcid.org/0000-0002-0343-4969)
- Sabry H. H. Youns
- Tarik A. Mohamed (ORCID: https://orcid.org/0000-0003-1639-3518)
- Paul W. Paré (ORCID: https://orcid.org/0000-0003-1644-723X)
- Khaled A. Shams (ORCID: https://orcid.org/0000-0002-5202-8692)
- Abdelaaty A. Shahat (ORCID: https://orcid.org/0000-0003-0456-3196)
- Abd El‐Nasser G. El Gendy
Institutions
- Texas Tech University (US)
- King Saud University (SA)
- National Centre for Research (Sudan) (SD)
- National Research Centre (EG)
- Sohag University (EG)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1080/14786419.2025.2583335
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00