Agreement and Clinical Utility of the Easytone Transpalpebral Tonometer Compared with Goldmann Applanation, Tono-Pen, and Icare in Healthy Eyes

<b>Objective:</b> To compare intraocular pressure (IOP) measurements obtained using the Easytone Transpalpebral Tonometer (ETT) with the Icare 200 (IC200), Tonopen AVIA (TPA), and Goldmann Applanation Tonometer (GAT) in healthy individuals. <b>Methods</b>: Fifty-eight right eyes of 58 healthy volunteers underwent IOP measurement with all four devices. Three consecutive readings were taken per device and averaged. Two masked observers performed all measurements. Agreement was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman analysis, and repeated-measures ANOVA compared mean IOP values. <b>Results:</b> Mean IOP values were 15.18 ± 1.88 mmHg (ETT), 14.45 ± 2.24 mmHg (TPA), 13.38 ± 2.65 mmHg (IC200), and 14.33 ± 2.03 mmHg (GAT) (<i>p</i> < 0.001). ETT provided significantly higher values than IC200, TPA, and GAT, while IC200 underestimated IOP compared with TPA and GAT. No difference was observed between TPA and GAT. Inter-observer agreement was excellent (ICC 0.805-1.000). Agreement analysis showed weaker ICC values for ETT-TPA (0.642) and ETT-IC200 (0.615). Bland-Altman plots confirmed the closest agreement between GAT and TPA, and the poorest agreement between ETT and IC200. <b>Conclusions:</b> ETT tends to overestimate and IC200 to underestimate IOP compared with GAT. TPA demonstrated the closest agreement with GAT and may be the most reliable alternative in clinical practice. ETT can be useful when applanation is not feasible, but its limited agreement should be considered.