Dual Contrast‐Enhanced Microcomputed Tomography Uncovers Leaflet‐Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis
Valvular calcification diverges from fibrous extracellular matrix remodeling but converges with adipocyte degeneration in terms of preferential impact on the noncoronary cusp versus, in particular, the LCC. Future mechanistic studies to elucidate the intimate relationship between adipocyte degeneration and valvular calcification may provide opportunities for further therapeutic development.
Authors
- Thomas A. Burdon
- Dale Burns (ORCID: https://orcid.org/0000-0001-6062-6230)
- Kristin C. Jensen (ORCID: https://orcid.org/0000-0003-1177-9104)
- Johanna Jimenez (ORCID: https://orcid.org/0000-0001-5947-0558)
- Yasuhiro Shudo (ORCID: https://orcid.org/0000-0002-4545-1273)
- Ian Y. Chen (ORCID: https://orcid.org/0000-0002-9694-5468)
- Lydia‐Marie Joubert (ORCID: https://orcid.org/0000-0002-4709-007X)
- Y. Joseph Woo (ORCID: https://orcid.org/0000-0002-2506-492X)
- John Perrino (ORCID: https://orcid.org/0000-0003-0825-3160)
- Artūras Vailionis (ORCID: https://orcid.org/0000-0001-5878-1864)
- Kevin Michael Alexander (ORCID: https://orcid.org/0000-0003-4024-3691)
- Mustapha El Zeini
- Tie Liang
- Angela Kabiri
- Ines Ross Tacco
Institutions
- Planetary Science Institute (US)
- VA Palo Alto Health Care System (US)
- Cardiovascular Institute of the South (US)
- SLAC National Accelerator Laboratory (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1161/jaha.124.040616
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00