Low Target Attainment of Intravenous Cefuroxime in Critically Ill Term Neonates and Children: A Pooled Population Pharmacokinetics Study
These findings indicate that underexposure due to augmented renal function is possible when applying the current cefuroxime dosing regimens. Future research should focus on individualized dosing strategies to optimize cefuroxime exposure and efficacy in pediatric populations.
Authors
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Alan Abdulla (ORCID: https://orcid.org/0000-0002-2158-6376)
- Roelie M. Wösten‐van Asperen (ORCID: https://orcid.org/0000-0002-2469-2131)
- Matthijs de Hoog (ORCID: https://orcid.org/0000-0002-1259-581X)
- Saskia N. de Wildt (ORCID: https://orcid.org/0000-0002-0502-0647)
- Stef Schouwenburg (ORCID: https://orcid.org/0000-0003-1835-0749)
- Stan J. F. Hartman (ORCID: https://orcid.org/0000-0003-3281-3244)
- Enno D. Wildschut (ORCID: https://orcid.org/0009-0005-5197-2656)
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Wilhelmina Children's Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s40262-025-01577-2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Erasmus Universitair Medisch Centrum Rotterdam