FLI1 Expression in Invasive Breast Carcinoma: Clinicopathological Correlations and Prognostic Implications
These findings highlight the dual role of FLI1: tumor-intrinsic FLI1 promotes proliferation and invasion, whereas its transcriptional regulation in tumor and endothelial compartments likely reflects LSD1 dependence. Collectively, our results support a mechanistic model in which LSD1-FLI1 crosstalk is involved in immune and stromal remodeling, positioning FLI1 as both a marker of tumor aggressiveness and a potential predictor of response to epigenetic therapies in breast cancer.
Authors
- Javed Akhter (ORCID: https://orcid.org/0000-0001-9076-508X)
- Qingfeng Chen (ORCID: https://orcid.org/0000-0001-6437-1271)
- Shahana Sultana (ORCID: https://orcid.org/0000-0001-5007-7637)
- Julekha Khatun
- Dong Yeul Lee
- Jabed Iqbal (ORCID: https://orcid.org/0000-0003-4137-1791)
- Arun Banu
- S. Chua
- Nusrat Jahan Doly
- Kazi Nafisa Tahsin
Institutions
- Agency for Science, Technology and Research (SG)
- Singapore General Hospital (SG)
- Green University of Bangladesh (BD)
- National Institute of Cardiovascular Diseases (BD)
- Institute of Molecular and Cell Biology (SG)
- Green Cross International (US)
- Dhaka Medical College and Hospital (BD)
Publication Details
- Journal
- Genes
- Published
- 2025-11-02
- DOI
- https://doi.org/10.3390/genes16111313
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00