Investigation of 6-thioguanine as a strategy to overcome methotrexate resistance in a mouse model of leptomeningeal carcinomatosis
Sequential 6-TG administration capitalizes on salvage pathway activation in MTX-resistant LC and may represent a promising therapeutic strategy to overcome MTX resistance.
Authors
- Masashi Kawaichi (ORCID: https://orcid.org/0000-0003-0860-467X)
- Masakazu Tamura
- Yoshihiro Yui (ORCID: https://orcid.org/0000-0002-5806-7801)
- Tsuyoshi Suzuki (ORCID: https://orcid.org/0000-0001-8920-9326)
- Masanobu Yamada (ORCID: https://orcid.org/0000-0002-2142-633X)
- Hidemitsu Nakagawa (ORCID: https://orcid.org/0009-0008-4400-7673)
Institutions
- Fukuoka Tokushukai Hospital (JP)
- Suita Tokushukai Hospital (JP)
- Kishiwada Tokushukai Hospital (JP)
- Osaka City University Hospital (JP)
- Nozaki Tokushukai Hospital
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s11060-025-05321-5
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00