Isoform-Specific Transcriptomic Effects of miR-133A1, miR-133A2, and miR-133B in a Colorectal Cancer Cell Line

These findings suggest that <i>miR-133</i> isoforms exert both shared and subtly divergent regulatory functions in colorectal cancer, coordinating apoptosis, proliferation, migration, and signaling network modulation. Isoform-specific transcriptional regulation of <i>miR-133</i> may contribute to tumor progression and represents a potential biomarker and therapeutic target in CRC.