Mitochondria-anchored aggregation-induced emission luminogens induce pyroptosis for enhanced photodynamic immunotherapy
In this study, we report a mitochondria-anchored, aggregation-induced emission photosensitizer named Kl-CHO. It has the ability to anchor mitochondria for an extended period. When subjected to light irradiation, the reactive oxygen species produced by Kl-CHO disrupt mitochondrial redox homeostasis. This causes mitochondrial dysfunction, which induces pyroptosis and amplifies cellular immunogenic death.
Authors
- Lei Hao (ORCID: https://orcid.org/0000-0001-5919-9331)
- Juyoung Yoon (ORCID: https://orcid.org/0000-0002-1728-3970)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-4900-5657)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0002-5702-3137)
- Ying Xie (ORCID: https://orcid.org/0000-0003-3223-1797)
- Haidong Li (ORCID: https://orcid.org/0000-0002-6634-9593)
- Jingyun Wang (ORCID: https://orcid.org/0000-0001-6835-2123)
- Haoyang Song (ORCID: https://orcid.org/0009-0002-7367-7752)
- Xiaotong Huo (ORCID: https://orcid.org/0009-0000-6142-8332)
Institutions
- Ewha Womans University (KR)
- Dalian University of Technology (CN)
- Dalian University (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04897d
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67