Dipeptidyl Peptidase 4, a Novel Adipokine, Impairs Retinal Microcirculation in Patients With Type 2 Diabetes Mellitus
Our results indicated that high serum DPP4 concentration may be associated with decreased RBF, probably via the constricted vessel D in men with type 2 diabetes with early-phase DR and further that DPP4 may inhibit endothelium-dependent NO-mediated dilation in the retinal arterioles via producing superoxide from NADPH oxidase.
Authors
- Tsuneaki Omae (ORCID: https://orcid.org/0000-0002-3900-0863)
- Taiji Nagaoka (ORCID: https://orcid.org/0000-0003-3933-1002)
- Harumasa Yokota (ORCID: https://orcid.org/0000-0003-1878-6032)
- Shinji Ono (ORCID: https://orcid.org/0000-0003-3727-7962)
- Shinichi Otani
- Takayuki Kamiya
Institutions
- Asahikawa Medical University (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1167/iovs.66.14.4
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71