Copper‐Catalyzed Ring‐Opening Cross‐Coupling of Cyclopropanols with Phosphorothioates
A copper-catalyzed ring-opening cross-coupling of cyclopropanols with phosphorothioates has been developed. This method efficiently affords diverse γ-carbonyl thiophosphates in medium to high yields under mild conditions. Herein, further studies demonstrate that these thiophosphates can be transformed into thiacyclobutanes with moderate efficiency. Initial mechanistic investigations suggest that the reaction proceeds via a radical pathway or homoenolate intermediate, rather than a Michael addition mechanism.
Authors
- Ying Luo (ORCID: https://orcid.org/0000-0001-9834-9419)
- Qiuling Song (ORCID: https://orcid.org/0000-0002-9836-8860)
- Cong Dong (ORCID: https://orcid.org/0000-0002-3125-7461)
- Jian Xu (ORCID: https://orcid.org/0009-0005-6798-8433)
- Yingying Yang (ORCID: https://orcid.org/0000-0002-1247-1112)
Institutions
- Huaqiao University (CN)
- Chinese Academy of Sciences (CN)
- Xinyu University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Henan Normal University (CN)
- Fuzhou University (CN)
- Fujian University of Technology (CN)
- Nanjing University (CN)
Publication Details
- Journal
- ChemSusChem
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1002/cssc.202501862
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Henan Normal University
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Huaqiao University
- Nanjing University
- State Key Laboratory of Coordination Chemistry