An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of total and free valproic acid in human serum and plasma
We present novel ID-LC-MS/MS-based cRMPs for total and free valproic acid in human serum and plasma which provides a traceable and reliable platform for the standardization of routine assays and evaluation of clinically relevant samples.
Authors
- Friederike Bauland
- Judith Taibon
- Christoph Seger (ORCID: https://orcid.org/0000-0002-3984-461X)
- Lorenz Risch (ORCID: https://orcid.org/0000-0003-2692-6699)
- Linda Salzmann
- Tobias Schierscher
- Andrea Geistanger (ORCID: https://orcid.org/0000-0002-5105-6026)
- Sarah Fleischer
- Neeraj Singh (ORCID: https://orcid.org/0000-0001-5004-232X)
- Cora Schäfer
- Julia Hoop
Institutions
- Roche Pharma AG (Germany) (DE)
- Labormedizinische Zentrum Dr Risch (Switzerland) (CH)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1515/cclm-2025-1053
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00