CO <sub>2</sub> -Promoted Direct Oxygenation of Benzylic sp <sup>3</sup> C–H Bonds Using Sodium Chlorite

Utilizing inexpensive and environmentally benign sodium chlorite, a CO<sub>2</sub>-promoted oxidation of benzylic sp<sup>3</sup> C-H bonds has been developed. In this process, CO<sub>2</sub> acts as an effective pH regulator, enabling the reaction to proceed under safe, mild conditions. Three classes of benzylic substrates, amines, ethers, and alkylarenes, can be effectively oxidized to their corresponding carbonyl products.

Authors

Changhu Chu (ORCID: https://orcid.org/0000-0002-4234-8123)
Chaoyang Liu (ORCID: https://orcid.org/0000-0002-8882-1182)
Ning Xu (ORCID: https://orcid.org/0000-0003-3219-4594)
Wenjing Gu (ORCID: https://orcid.org/0000-0003-1604-7666)
Lanling Zhang
Lei Ma (ORCID: https://orcid.org/0000-0003-1412-3864)

Institutions

East China University of Science and Technology (CN)

Publication Details

Journal: The Journal of Organic Chemistry
Published: 2025-11-03
DOI: https://doi.org/10.1021/acs.joc.5c02036
Primary Topic: Catalytic C–H Functionalization Methods
Type: article
Field-Weighted Citation Impact: 0.00

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article

CO ₂ -Promoted Direct Oxygenation of Benzylic sp ³ C–H Bonds Using Sodium Chlorite

Changhu Chu, Chaoyang Liu, Ning Xu, Wenjing Gu et al.

Nov 3, 2025

The Journal of Organic Chemistry

Catalytic C–H Functionalization Methods

article

CO ₂ -Promoted Direct Oxygenation of Benzylic sp ³ C–H Bonds Using Sodium Chlorite

Changhu Chu, Chaoyang Liu, Ning Xu, Wenjing Gu, Lanling Zhang, Lei Ma

November 3, 2025article en

Abstract

Utilizing inexpensive and environmentally benign sodium chlorite, a CO<sub>2</sub>-promoted oxidation of benzylic sp<sup>3</sup> C-H bonds has been developed. In this process, CO<sub>2</sub> acts as an effective pH regulator, enabling the reaction to proceed under safe, mild conditions. Three classes of benzylic substrates, amines, ethers, and alkylarenes, can be effectively oxidized to their corresponding carbonyl products.

The Journal of Organic ChemistryVol. 90(45)

East China University of Science and Technology (CN)

Openalex Percentile: Top 75%

Catalytic C–H Functionalization Methods

DOI Source OpenAlex

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