Lymphocytes and immunoglobulins in peripheral blood and lymphatic fluid of neonates with chylothorax
Our findings confirm a specific pattern of immune dysregulation in neonates with chylothorax, with distinct lymphocyte and immunoglobulin profiles in chyle. In particular, the T-cell subsets were enriched in the chyle. A multicenter, prospective randomized trial is warranted to assess the utility of immunoglobulin therapy in infection prevention in this population.
Authors
- Francesca Landolfo (ORCID: https://orcid.org/0000-0002-5445-7511)
- Filippo Gazzotti
- Paola Giliberti (ORCID: https://orcid.org/0000-0002-5756-8735)
- Flaminia Pugnaloni (ORCID: https://orcid.org/0000-0001-9509-6778)
- Claudia Capponi
- Andrea Dotta (ORCID: https://orcid.org/0000-0002-1260-6427)
- Ludovica Martini (ORCID: https://orcid.org/0000-0002-3090-5949)
- Ottavia Porzio (ORCID: https://orcid.org/0000-0001-5931-8679)
- Claudia Columbo
- Andrea Conforti (ORCID: https://orcid.org/0000-0002-0191-1880)
- Domenico Umberto De Rose (ORCID: https://orcid.org/0000-0002-9076-9838)
- Irma Capolupo (ORCID: https://orcid.org/0000-0002-3090-2887)
- Alessandra Santisi
- Guglielmo Salvatori (ORCID: https://orcid.org/0000-0001-8761-8732)
- Carlo Federico Perno (ORCID: https://orcid.org/0000-0002-0825-5388)
- Maria Paola Ronchetti (ORCID: https://orcid.org/0000-0001-9851-1957)
- Fatima Zahra Gassabi
Institutions
- University of Rome Tor Vergata (IT)
- Bambino Gesù Children's Hospital (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1666366
- Primary Topic
- Lymphatic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute