Epiregulin drives keratinocyte hyperproliferation in sorafenib-induced hand-foot skin reaction: A mechanistic and therapeutic insight
The present findings identify EREG as a critical mediator of keratinocyte hyperproliferation in sorafenib-induced HFSR, offering a novel therapeutic target. Moreover, EREG expression may serve as a predictive biomarker for HFSR severity, guiding personalized prophylaxis. Clinical exploration of EREG inhibition could provide a tailored approach to alleviate HFSR, improving patient adherence and treatment outcomes.
Authors
- Zhengwei Leng (ORCID: https://orcid.org/0000-0001-5740-7715)
- Xiaorong Zhong (ORCID: https://orcid.org/0000-0003-1812-7213)
- Hong Xiao (ORCID: https://orcid.org/0000-0003-1184-4279)
- Yuxin Liang (ORCID: https://orcid.org/0000-0001-6872-5030)
- Jinlong Zhao (ORCID: https://orcid.org/0000-0001-7079-1336)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7870-0646)
- Ke Chen (ORCID: https://orcid.org/0000-0002-2098-1921)
- Li Zhao (ORCID: https://orcid.org/0000-0002-1378-7434)
- Jianlin Wu (ORCID: https://orcid.org/0000-0002-4890-8494)
- Guojun Zhou
- Xiaolun Huang (ORCID: https://orcid.org/0000-0002-4993-0802)
Institutions
- North Sichuan Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Clinics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.clinsp.2025.100809
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00