Abstract 4366061: Global, Regional, and National Trends in Mortality and Disability-Adjusted Life Years (DALYs) Associated with High BMI in Adolescents (1990–2021): A Comprehensive Epidemiological Analysis

Background: High body mass index (BMI) in adolescents is closely associated with various chronic diseases (e.g., cardiovascular diseases, diabetes) and has become a significant global health concern. However, comprehensive studies on global trends in mortality and disability-adjusted life years (DALYs) associated with high BMI in adolescents remain limited. This study aims to analyze the epidemiological trends of mortality and DALYs associated with high BMI in adolescents at the global, regional, and national levels from 1990 to 2021. Methods: Utilizing the Global Burden of Disease (GBD) database, this study analyzed mortality and DALYs associated with high BMI in adolescents (aged 10-19 years) across 204 countries and territories from 1990 to 2021. Data were stratified by age, sex, geographic location, and Socio-demographic Index (SDI). Joinpoint regression models were used to calculate the annual percent change (APC), and log-transformed linear regression models were employed to estimate the average annual percentage change (EAPC). Results: From 1990 to 2021, global mortality and DALYs associated with high BMI in adolescents showed an overall increasing trend. High SDI regions exhibited a declining trend in mortality and DALYs, while low and low-middle SDI regions experienced an increasing trend. Boys generally had higher mortality and DALYs rates than girls. Conclusion: Global mortality and DALYs associated with high BMI in adolescents showed an overall increasing trend, particularly in low and low-middle SDI regions. The findings underscore the importance of strengthening early intervention and treatment in these regions and provide crucial data for global public health policymakers.