Mechanism of Coptisine in Rotator Cuff Injury: PI3K/Akt/mTORinflammation Crosstalk Uncovered by Network Pharmacology and Experimental Validation
Coptisine improved RCI in rats by decreasing inflammation and the PI3K/Akt/ mTOR pathway, suggesting a possible therapeutic target for RCI.
Authors
- Jingyu Shang (ORCID: https://orcid.org/0000-0001-5066-0005)
- Hengxu Zhang (ORCID: https://orcid.org/0000-0001-5315-0887)
- Zhufeng Yuan (ORCID: https://orcid.org/0009-0005-1532-6227)
- Yufeng Wang (ORCID: https://orcid.org/0000-0002-7470-4938)
- Zhiyuan Wang (ORCID: https://orcid.org/0000-0002-3381-9931)
- Shilong Wang (ORCID: https://orcid.org/0000-0001-5571-8798)
- Guang Hu (ORCID: https://orcid.org/0000-0003-3895-1744)
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- Current Computer - Aided Drug Design
- Published
- 2025-10-31
- DOI
- https://doi.org/10.2174/0115734099394549251014152637
- Citations
- 1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01