Comprehensive Analysis Identifies Tumor Mutation Burden-associated Genes ASPM and KIF11 as Novel Biomarkers for Adrenocortical Carcinoma
A total of eight candidate TMB-related prognostic genes (including ASPM, BIRC5, BUB1, CDC20, CDCA5, CEP55, KIF11, and TPX2) for ACC patients were identified. Preliminary experimental verification revealed that ASPM and KIF11 could promote the proliferation of ACC cells and ACC tumor growth in vivo.
Authors
- Qi You (ORCID: https://orcid.org/0000-0002-1358-2973)
- Shih‐Wei Lin (ORCID: https://orcid.org/0000-0002-7915-0014)
- Shao‐Hao Chen (ORCID: https://orcid.org/0000-0002-7243-4428)
- Jia‐Yin Chen
- Xue‐Yi Xue (ORCID: https://orcid.org/0000-0002-6461-7435)
- Zhi‐Bin Ke (ORCID: https://orcid.org/0000-0002-7563-7781)
- Qing‐Shui Zheng (ORCID: https://orcid.org/0000-0002-7426-6501)
- Ning Xu (ORCID: https://orcid.org/0000-0001-7909-7025)
- Mingqiang Lin (ORCID: https://orcid.org/0009-0008-8878-4677)
- Yu‐Ting Xue
- Yong Wei (ORCID: https://orcid.org/0000-0001-5324-3733)
- Jiang‐Bo Sun
- Xiaodong Li (ORCID: https://orcid.org/0000-0003-2394-1340)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-10-31
- DOI
- https://doi.org/10.2174/0115680096396835251019170810
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00