Triptonide Mediates Apoptosis and Autophagy via ROS/p38 MAPK Activation and mTOR/NF-κB Inhibition in Nasopharyngeal Carcinoma: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation
TN demonstrates potential as a therapeutic agent for NPC, primarily through activation of the MAPK signaling pathway and autophagy. Key targets, including RELA, CASP8, PPARG, MAPK14, MAPK8, HDAC1, ERBB2, and CASP1, have been identified as critical mediators of TN's effects, highlighting its role in promoting autophagy and enhancing NPC treatment.
Authors
- Jiade J. Lu (ORCID: https://orcid.org/0000-0001-7163-9539)
- Ziyu Le
- Huaiyuan Chen (ORCID: https://orcid.org/0009-0002-9831-7374)
- Lin Kong (ORCID: https://orcid.org/0000-0002-5263-5740)
- Qingting Huang (ORCID: https://orcid.org/0000-0002-9488-5983)
- Wanzun Lin (ORCID: https://orcid.org/0000-0003-3973-8849)
- Fangzhu Wan
- Shikai Geng (ORCID: https://orcid.org/0000-0003-2312-0569)
- Fengtao Su (ORCID: https://orcid.org/0000-0003-1836-4606)
- Li Chen (ORCID: https://orcid.org/0000-0002-9478-6432)
- Wei Hu (ORCID: https://orcid.org/0000-0003-4160-6597)
- Chunlin Shao
- Xingyu Liu (ORCID: https://orcid.org/0009-0008-8093-1767)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Foshan Hospital of TCM (CN)
- Center for High Pressure Science & Technology Advanced Research (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-10-31
- DOI
- https://doi.org/10.2174/0113816128392691251008235211
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00