The effects of L-tartaric acid on diabetic cataracts through modulation of oxidative stress and inflammation in diabetic rats
L‑tartaric acid significantly reduces oxidative damage and inflammation in the lens, and shows potential in protecting against diabetic cataract by reinforcing the endogenous antioxidant defense network and moderating inflammatory processes. These data suggest that L‑tartaric acid may serve as a promising adjunct therapy to curb the onset and progression of diabetic cataract, possibly through mechanisms independent of glycemic control. Further studies, including topical formulations and well-designed human clinical trials, are needed to validate these preliminary observations.
Authors
- Haijun Yang (ORCID: https://orcid.org/0000-0002-8488-2025)
- Meng Li (ORCID: https://orcid.org/0000-0002-1749-9253)
- Shengyu Wang (ORCID: https://orcid.org/0000-0002-9774-8319)
Institutions
- Anyang Eye Hospital (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12886-025-04409-w
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00