The effects of L-tartaric acid on diabetic cataracts through modulation of oxidative stress and inflammation in diabetic rats

L‑tartaric acid significantly reduces oxidative damage and inflammation in the lens, and shows potential in protecting against diabetic cataract by reinforcing the endogenous antioxidant defense network and moderating inflammatory processes. These data suggest that L‑tartaric acid may serve as a promising adjunct therapy to curb the onset and progression of diabetic cataract, possibly through mechanisms independent of glycemic control. Further studies, including topical formulations and well-designed human clinical trials, are needed to validate these preliminary observations.

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Publication Details

Journal
BMC Ophthalmology
Published
2025-11-03
DOI
https://doi.org/10.1186/s12886-025-04409-w
Primary Topic
Connexins and lens biology
Type
article
Field-Weighted Citation Impact
0.00
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article

The effects of L-tartaric acid on diabetic cataracts through modulation of oxidative stress and inflammation in diabetic rats

Haijun Yang, Meng Li, Shengyu Wang
BMC Ophthalmology
Connexins and lens biology
article

The effects of L-tartaric acid on diabetic cataracts through modulation of oxidative stress and inflammation in diabetic rats

Haijun Yang, Meng Li, Shengyu Wang
article en

Abstract

L‑tartaric acid significantly reduces oxidative damage and inflammation in the lens, and shows potential in protecting against diabetic cataract by reinforcing the endogenous antioxidant defense network and moderating inflammatory processes. These data suggest that L‑tartaric acid may serve as a promising adjunct therapy to curb the onset and progression of diabetic cataract, possibly through mechanisms independent of glycemic control. Further studies, including topical formulations and well-designed human clinical trials, are needed to validate these preliminary observations.

BMC OphthalmologyVol. 25(1)
Anyang Eye Hospital (CN), First Hospital of Xi'an (CN)
Openalex Percentile: Top 71%
Connexins and lens biology
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