Thiamine use and short-term prognosis in critical cerebrovascular disease: a propensity score matched retrospective analysis from the MIMIC-IV database
Thiamine supplementation correlated with a reduction in short-term mortality for patients with critical cerebrovascular conditions, especially with prolonged treatment and reduced daily doses. While these observations propose thiamine as a possible supportive metabolic therapy, the evidence remains insufficient to guide clinical practice and should be considered hypothesis-generating pending confirmation in randomized trials.
Authors
- Tianli Zhang (ORCID: https://orcid.org/0000-0001-5423-2681)
- Minheng Zhang (ORCID: https://orcid.org/0009-0007-3213-6622)
- Wei Peng (ORCID: https://orcid.org/0000-0002-2437-3923)
- Xuan Chen (ORCID: https://orcid.org/0009-0009-3747-123X)
- Xin Li (ORCID: https://orcid.org/0000-0002-7414-5734)
- Haixia Fan (ORCID: https://orcid.org/0009-0007-6404-2997)
- Z X Yin (ORCID: https://orcid.org/0009-0006-3342-4311)
Institutions
- Shanxi Medical University (CN)
- Second People 's Hospital of Jinzhong (CN)
- First Hospital of Shanxi Medical University (CN)
- Second Hospital of Tianjin Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12883-025-04478-w
- Citations
- 1
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Tianjin Municipal Health Commission