FAM3B overexpression correlates with poor prognosis and immune dysregulation in colorectal cancer: insights from bioinformatics and Mendelian randomization analyses
High FAM3B expression levels are correlated with poor prognosis and advanced tumor stages in CRC patients, likely influencing CRC development by regulating the tumor microenvironment characteristics. These findings suggest that FAM3B could be a potential CRC therapeutic target, and the constructed clinical predictive model offers new insights for the diagnosis and treatment of CRC patients.
Authors
- Chengshuo Zhang (ORCID: https://orcid.org/0000-0001-9679-5271)
- Peng Fei Huang (ORCID: https://orcid.org/0000-0003-3651-7813)
- Pei Li (ORCID: https://orcid.org/0000-0001-9596-3122)
- Jialin Zhang (ORCID: https://orcid.org/0000-0002-7131-0677)
Institutions
- First Hospital of China Medical University (CN)
- Jiangjin Central Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s12672-025-03842-z
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00