DNMT3B blocks TAL1-mediated PKM2 transcriptional repression to promote non-small cell lung cancer progression through inducing glycolysis

DNMT3B activates glycolysis and promotes NSCLC progression by mediating methylation modification of TAL1 and inducing PKM2 transcription.

Authors

Changying Guo (ORCID: https://orcid.org/0000-0002-7992-565X)
Shidang Xu (ORCID: https://orcid.org/0000-0002-7013-3672)
Zhao Zhao (ORCID: https://orcid.org/0000-0001-7901-500X)
Yucheng Guo (ORCID: https://orcid.org/0000-0002-0743-0308)
Li Zhao (ORCID: https://orcid.org/0000-0001-7444-9845)
Weimin Mao (ORCID: https://orcid.org/0000-0001-7495-127X)
Zhengzhou Qiu

Institutions

First Affiliated Hospital of Jiangxi Medical College (CN)
Jiangxi Provincial Cancer Hospital (CN)
Wuchang University of Technology (CN)

Publication Details

Journal: Cell Division
Published: 2025-11-03
DOI: https://doi.org/10.1186/s13008-025-00168-8
Primary Topic: Epigenetics and DNA Methylation
Type: article
Field-Weighted Citation Impact: 0.00

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article

DNMT3B blocks TAL1-mediated PKM2 transcriptional repression to promote non-small cell lung cancer progression through inducing glycolysis

Changying Guo, Shidang Xu, Zhao Zhao, Yucheng Guo et al.

Nov 3, 2025

Cell Division

Epigenetics and DNA Methylation

article

DNMT3B blocks TAL1-mediated PKM2 transcriptional repression to promote non-small cell lung cancer progression through inducing glycolysis

Changying Guo, Shidang Xu, Zhao Zhao, Yucheng Guo, Li Zhao, Weimin Mao, Zhengzhou Qiu

November 3, 2025article en

Abstract

DNMT3B activates glycolysis and promotes NSCLC progression by mediating methylation modification of TAL1 and inducing PKM2 transcription.

Cell DivisionVol. 20(1)

First Affiliated Hospital of Jiangxi Medical College (CN), Jiangxi Provincial Cancer Hospital (CN), Wuchang University of Technology (CN)

Openalex Percentile: Top 71%

Epigenetics and DNA Methylation

DOI Open Access PDF OpenAlex

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DNMT3B blocks TAL1-mediated PKM2 transcriptional repression to promote non-small cell lung cancer progression through inducing glycolysis — Changying Guo, Shidang Xu, et al. · Cell Division (2025) | TGRS Research Map | TGRS