Abstract 4361958: Does invasive hemodynamic monitoring reduce mortality? A Meta-Analysis of pulmonary artery catheterization in cardiogenic shock

Introduction: Cardiogenic shock is a life-threatening complication of decompensated heart failure, with elevated in-hospital mortality rates despite advances in treatment. Pulmonary artery catheterization (PAC) provides detailed hemodynamic data that may guide therapy in shock states, yet its routine use has declined following neutral trials in broader heart failure populations. The benefit of PAC in patients with cardiogenic shock remains uncertain. Research question: In patients with cardiogenic shock, does the use of pulmonary artery catheter compared to standard therapy reduce in-hospital mortality? Methods: We conducted a systematic review and meta-analysis including both observational studies and randomized controlled trials that compared the use of PAC versus no PAC in patients with cardiogenic shock. A comprehensive search was carried out in PubMed, Scopus, Cochrane CENTRAL, and Web of Science databases. Data were pooled using a random-effects model, and the certainty of the evidence was assessed using the GRADE approach. Primary outcomes included mortality, while secondary outcomes were length of hospital stay and procedure-related complications. Results: Nine studies including over 1.1 million patients with cardiogenic shock were analyzed. PAC was not associated with reduced in-hospital mortality compared to no PAC (RR 1.25, 95% CI 0.62–2.49; p=0.48). No significant differences were found in the use of vasoactive agents (RR 1.12, 95% CI 0.94–1.34; p=0.13), renal replacement therapy (RR 1.06, 95% CI 0.25–4.53; p=0.90), intra-aortic balloon pump (RR 2.00, 95% CI 0.84–4.73; p=0.09), ECMO (RR 1.03, 95% CI 0.40–2.64; p=0.95), or durable ventricular assist device implantation (RR 2.48, 95% CI 0.45–13.70; p=0.21). All outcomes showed high heterogeneity and wide prediction intervals, indicating substantial variability and uncertainty in treatment effects across studies. Conclusion: PAC was not associated with significant benefits in mortality or major clinical endpoints. These findings suggest that PAC use should be individualized, and highlight the need for prospective trials to better define which patients may derive benefit from invasive hemodynamic monitoring.