Dynamic excitation/inhibition balance preceding seizure onset and its link to functional and structural brain architecture
Seizure onset is preceded by a widespread shift toward inhibition, possibly representing a compensatory mechanism that fails as ictal thresholds are crossed. This shift is linked to altered connectivity and disrupted structure-function coupling in epileptic regions. The dynamic aperiodic exponent emerges as a promising biomarker for seizure prediction and a potential target for neuromodulation strategies.
Authors
- Justine Y. Hansen (ORCID: https://orcid.org/0000-0003-3142-7480)
- Alberto Danieli (ORCID: https://orcid.org/0000-0002-8390-5897)
- Lisa Antoniazzi (ORCID: https://orcid.org/0000-0001-8895-3380)
- Gian Marco Duma (ORCID: https://orcid.org/0000-0002-0778-3920)
- Simone Cuozzo (ORCID: https://orcid.org/0000-0002-1867-6151)
- Paolo Bonanni (ORCID: https://orcid.org/0000-0002-9448-9059)
- Elisa Osanni
- Valerio Vitale (ORCID: https://orcid.org/0000-0001-8042-3959)
- Giovanni Pellegrino (ORCID: https://orcid.org/0000-0002-1195-1421)
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- IRCCS Eugenio Medea (IT)
- Ospedale San Bortolo (IT)
- McGill University (CA)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12916-025-04447-7
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43