Qingre Huoxue decoction and its active compound Quercetin modulate bone remodeling by inhibiting ATF4 hyperactivation to attenuate bone erosion in rheumatoid arthritis
QRHXD attenuates bone erosion in RA by inhibiting ATF4 hyperactivation via Quercetin, restoring osteoblast-osteoclast crosstalk.
Authors
- Chuanhui Yao
- Xiaopo Tang (ORCID: https://orcid.org/0000-0002-0569-4502)
- Xun Gong (ORCID: https://orcid.org/0000-0002-3377-0373)
- Quan Jiang (ORCID: https://orcid.org/0000-0003-2944-154X)
- Congmin Xia
- Fuyuan Zhang (ORCID: https://orcid.org/0000-0002-9910-8681)
- Mengge Song (ORCID: https://orcid.org/0000-0001-7353-9099)
- Chang Tian (ORCID: https://orcid.org/0009-0001-4387-2971)
- Qiuwei Peng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s13018-025-06333-7
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China