Abstract Sat1405: Racial Disparities in Cardiovascular Outcomes Following Cardiac Arrest: A Real-World Analysis Using the TriNetX Database

Background: Cardiac arrest is a critical medical emergency with high mortality rates. Despite advancements in medicine, racial disparities in outcomes continue to be a significant concern. Using the TriNetX database, a large real-world database, this study investigates racial disparities in outcomes following cardiac arrest. By analyzing differences in outcomes, we aim to highlight inequities and inform strategies for promoting more equitable treatment and outcomes. Methods: This retrospective cohort study utilized data from the TriNetX Research Network, a federated database aggregating de-identified electronic health records from multiple healthcare organizations across the United States. We identified adult patients (≥18 - 99 years) with a diagnosis of cardiac arrest between January 2005 and December 2024 and tracked outcomes for a maximum of 10 years. Primary outcomes assessed included all-cause mortality, and secondary cardiovascular outcomes included acute myocardial infarction, stroke, atrial fibrillation, ventricular tachycardia, and heart failure. Statistical significance was defined as p < 0.05. All analyses were conducted using the TriNetX analytics platform. Results: Our initial cohort consisted of 283,180 White patients and 143,450 non-White patients (including Black or African American, Hispanic or Latino, Other race, or Asian). After propensity score matching (n = 136,577 per cohort), Non-White patients with cardiac arrest had significantly higher mortality compared to White patients (59.8% vs. 56.3%, p < 0.001). Median survival was shorter in Non-White patients (31 vs. 63 days). White patients exhibited higher risks of acute myocardial infarction, atrial fibrillation, ventricular tachycardia, and heart failure (all p < 0.001), while Non-White patients had worse overall survival outcomes. Conclusion: These findings highlight persistent racial disparities in post-cardiac arrest outcomes despite adjustment for comorbidities.