Lily polysaccharides alleviate colitis through the microbiota–N8-acetylspermidine–cGAS–STING signaling axis
LP exerts anti-colitic activity through the microbiota/N8AS/cGAS-STING axis, linking microbial regulation, metabolic modulation, and immune signaling suppression. These findings support LP as a promising natural therapeutic for UC and provide novel insights into the beneficial effects and preliminary mechanisms of N8AS.
Authors
- Junwei Shao (ORCID: https://orcid.org/0000-0002-7418-0230)
- Haolong Zhang
- Jialin Wang (ORCID: https://orcid.org/0000-0001-8145-8993)
- Yuanyu Wu (ORCID: https://orcid.org/0000-0002-0071-8886)
- Xiaoyu Wan
- Kun Wu (ORCID: https://orcid.org/0000-0002-5199-9921)
- Lu Hou
- Zheyu Song
Institutions
- Jilin University (CN)
- Changchun University of Chinese Medicine (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fmicb.2025.1686902
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jilin Province
- People's Government of Jilin Province